South America Cruise Deals

There's so much to explore on a cruise around South America, from sun-drenched coastal resorts and cosmopolitan cities, to lush rainforests and UNESCO world heritage sites. To find out more and discover the very best deals and prices call us today and speak to our cruise holiday experts.

Find Out More About Cruising South America

Showing 30 out of 2555 cruises
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Was £2229pp Now: £2139pp

14-Day Panama Canal

Fort Lauderdale | Cartagena | Puntarenas | Puerto Quetzal | Huatulco (Santa María Huatulco) | Puerto Vallarta | San Diego

  • 03 Apr 2027
  • 14 Nights
Cruise From:
Was £2229pp Now: £2139pp
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Holiday ID: 026138
Cruise From:
Was £8124pp Now: £7799pp

7 Night Galapagos Inner Loop Itinerary

Baltra Island | Rabida Island | Puerto Egas | Elizabeth Bay | Tagus Cove | Bartolome Island | Sullivan Bay | Daphne Major | North Seymour Island | Las Bachas | Punta Pitt | Puerto Baquerizo Moreno | Puerto Ayora | Baltra Island

  • 13 Aug 2028
  • 7 Nights
Cruise From:
Was £8124pp Now: £7799pp
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Holiday ID: 071680
Cruise From:
£366pp

7 Night Ensenada, Cabo & Mazatlan

Los Angeles | Ensenada | Cabo San Lucas | Mazatlán | Los Angeles

  • 19 Feb 2027
  • 7 Nights
Cruise From:
£366pp
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Holiday ID: 024828
Cruise From:
£4710pp

Fuerte Amador (Panama City) to New York

Fuerte Amador | Cartagena | Port Antonio | Montego Bay | Georgetown | Miami | Port Canaveral | Norfolk | New York

  • 20 Aug 2027
  • 14 Nights
Cruise From:
£4710pp
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Holiday ID: 032801
Cruise From:
Was £10588pp Now: £10164pp

7 Night Galapagos Outer Loop Cruise

Baltra Island | Punta Suarez | Gardner Bay | Floreana Island | Punta Cormorant | Elizabeth Bay | Urbina Bay | Vincente Roca Point | Punta Espinoza | Daphne Major | South Plaza Island | Dragon Hill | Puerto Ayora | Baltra Island

  • 16 May 2027
  • 7 Nights
Cruise From:
Was £10588pp Now: £10164pp
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Holiday ID: 026833
Cruise From:
Was £426pp Now: £413pp

6-Day Mexican Riviera

Long Beach | Cabo San Lucas | Ensenada | Long Beach

  • 20 Dec 2026
  • 6 Nights
Cruise From:
Was £426pp Now: £413pp
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Holiday ID: 021789
Cruise From:
Was £3019pp Now: £2898pp

20-Day Panama Canal

Fort Lauderdale | Cartagena | Puntarenas | Puerto Quetzal | Huatulco (Santa María Huatulco) | Puerto Vallarta | San Diego | San Francisco | Vancouver

  • 03 Apr 2027
  • 20 Nights
Cruise From:
Was £3019pp Now: £2898pp
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Holiday ID: 026137
Cruise From:
£9170pp

Buenos Aires to Valparaiso, Chile

Buenos Aires | Punta del Este | Puerto Madryn | Port Stanley | Ushuaia | Punta Arenas | Chilean Fjords | Laguna San Rafael National Park | Puerto Chacabuco | Castro | Puerto Montt | Valparaiso

  • 11 Nov 2027
  • 18 Nights
Cruise From:
£9170pp
View cruise
Holiday ID: 032809
Fly Cruise From:
£1714pp

7 Night Southern Caribbean Cruise

Colón | Cartagena | Santa Marta | Oranjestad | Willemstad | Colón

  • 30 Jan 2027
  • 7 Nights
Fly Cruise From:
£1714pp
View cruise
Holiday ID: 043190
Cruise From:
Was £1009pp Now: £968pp

18 Night Panama Canal Eastbound Cruise

Los Angeles | Puerto Vallarta | Puerto Quetzal | Puntarenas | Cartagena | Grand Turk Island | Boston

  • 18 Sep 2027
  • 18 Nights

Interest free Monthly Payments from JUST £115pp

Cruise From:
Was £1009pp Now: £968pp
View cruise
Holiday ID: 052303
Cruise From:
Was £840pp Now: £814pp

Panama Canal: Bahamas & Costa Rica

Miami | Great Stirrup Cay | Cabo Rojo | Oranjestad | Willemstad | Cartagena | Colón | Gatun Lake | Puerto Limón | Miami

  • 21 Dec 2026
  • 12 Nights
Cruise From:
Was £840pp Now: £814pp
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Holiday ID: 018115
Cruise From:
Was £7316pp Now: £7023pp

7 Night Galapagos Outer Loop Itinerary

Baltra Island | Punta Suarez | Gardner Bay | Floreana Island | Punta Cormorant | Elizabeth Bay | Urbina Bay | Vincente Roca Point | Punta Espinoza | Daphne Major | South Plaza Island | Dragon Hill | Puerto Ayora | Baltra Island

  • 09 Jan 2028
  • 7 Nights
Cruise From:
Was £7316pp Now: £7023pp
View cruise
Holiday ID: 071673
Fly Cruise From:
£1340pp

3 Night Ensenada Cruise

Los Angeles | Ensenada | Los Angeles

  • 02 Apr 2027
  • 3 Nights
Fly Cruise From:
£1340pp
View cruise
Holiday ID: 024704
Cruise From:
Was £8195pp Now: £7867pp

7 Night Galapagos Outer Loop Cruise

Baltra Island | Punta Suarez | Gardner Bay | Floreana Island | Punta Cormorant | Elizabeth Bay | Urbina Bay | Vincente Roca Point | Punta Espinoza | Daphne Major | South Plaza Island | Dragon Hill | Puerto Ayora | Baltra Island

  • 05 Sep 2027
  • 7 Nights
Cruise From:
Was £8195pp Now: £7867pp
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Holiday ID: 026842
Cruise From:
Was £2589pp Now: £2485pp

14-Day Mexican Riviera & Baja Peninsula Holiday

San Diego | Cabo San Lucas | La Paz | Mazatlán | San Diego | Puerto Vallarta | Mazatlán | Cabo San Lucas | San Diego

  • 19 Dec 2026
  • 14 Nights
Cruise From:
Was £2589pp Now: £2485pp
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Holiday ID: 026154
Cruise From:
Was £699pp Now: £657pp

South America 7 Nights From Maceió

Maceió | Santos | Buzios | Salvador de Bahia | Maceió

  • 09 Dec 2026
  • 7 Nights
Cruise From:
Was £699pp Now: £657pp
View cruise
Holiday ID: 049627
Cruise From:
Was £8789pp Now: £8437pp

7 Night Galapagos Outer Loop Cruise

Baltra Island | Punta Suarez | Gardner Bay | Floreana Island | Punta Cormorant | Elizabeth Bay | Urbina Bay | Vincente Roca Point | Punta Espinoza | Daphne Major | South Plaza Island | Dragon Hill | Puerto Ayora | Baltra Island

  • 03 Oct 2027
  • 7 Nights
Cruise From:
Was £8789pp Now: £8437pp
View cruise
Holiday ID: 026818
Fly Cruise From:
£2173pp

7 Night Southern Caribbean Cruise

Colón | Cartagena | Oranjestad | Willemstad | Colón

  • 20 Feb 2027
  • 7 Nights
Fly Cruise From:
£2173pp
View cruise
Holiday ID: 043228
Fly Cruise From:
£1999pp

7 Night Southern Caribbean Cruise

Cartagena | Santa Marta | Willemstad | Oranjestad | Colón | Cartagena

  • 24 Jan 2027
  • 7 Nights
Fly Cruise From:
£1999pp
View cruise
Holiday ID: 043233
Cruise From:
Was £8237pp Now: £7899pp

7 Night Galapagos Outer Loop Cruise

Baltra Island | Punta Suarez | Gardner Bay | Floreana Island | Punta Cormorant | Elizabeth Bay | Urbina Bay | Vincente Roca Point | Punta Espinoza | Daphne Major | South Plaza Island | Dragon Hill | Puerto Ayora | Baltra Island

  • 08 Aug 2027
  • 7 Nights
Cruise From:
Was £8237pp Now: £7899pp
View cruise
Holiday ID: 026850
Cruise From:
Was £759pp Now: £713pp

South America 7 Nights From Santos

Santos | Buzios | Salvador de Bahia | Maceió | Santos

  • 06 Feb 2027
  • 7 Nights
Cruise From:
Was £759pp Now: £713pp
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Holiday ID: 049652
Cruise From:
Was £22312pp Now: £20973pp

San Cristóbal to San Cristóbal

San Cristóbal Island | Roca León Dormido | Bartolome Island | Santiago Island | Punta Vicente Roca | Punta Espinoza | Elizabeth Bay | Caleta Tagus | Champion Island | Post Office Bay | Punta Cormorant | Los Gemelos | Puerto Ayora | Santa Cruz Island | Isla Guy Fawkes | Dragon Hill | San Cristóbal Island

  • 25 Dec 2027
  • 7 Nights
Cruise From:
Was £22312pp Now: £20973pp
View cruise
Holiday ID: 050293
Cruise From:
£575pp

Mexican Riviera: Cabo San Lucas & Puerto Vallarta

San Diego | Cabo San Lucas | Mazatlán | Puerto Vallarta | San Diego

  • 26 Dec 2026
  • 7 Nights
Cruise From:
£575pp
View cruise
Holiday ID: 018542
Cruise From:
Was £8744pp Now: £8394pp

7 Night Galapagos Outer Loop Itinerary

Baltra Island | Punta Suarez | Gardner Bay | Floreana Island | Punta Cormorant | Elizabeth Bay | Urbina Bay | Vincente Roca Point | Punta Espinoza | Daphne Major | South Plaza Island | Dragon Hill | Puerto Ayora | Baltra Island

  • 09 Jul 2028
  • 7 Nights
Cruise From:
Was £8744pp Now: £8394pp
View cruise
Holiday ID: 071674
Cruise From:
Was £218pp Now: £211pp

5-Day Mexican Riviera

Long Beach | Cabo San Lucas | Ensenada | Long Beach

  • 09 Feb 2027
  • 5 Nights
Cruise From:
Was £218pp Now: £211pp
View cruise
Holiday ID: 021809
Cruise From:
Was £12331pp Now: £11837pp

7 Night Galapagos Outer Loop Cruise - New Years At Sea

Baltra Island | Punta Suarez | Gardner Bay | Floreana Island | Punta Cormorant | Elizabeth Bay | Urbina Bay | Vincente Roca Point | Punta Espinoza | Daphne Major | South Plaza Island | Dragon Hill | Puerto Ayora | Baltra Island

  • 26 Dec 2027
  • 7 Nights
Cruise From:
Was £12331pp Now: £11837pp
View cruise
Holiday ID: 026848
Fly Cruise From:
£1963pp

7 Night Southern Caribbean Cruise

Colón | Cartagena | Oranjestad | Willemstad | Colón

  • 03 Apr 2027
  • 7 Nights
Fly Cruise From:
£1963pp
View cruise
Holiday ID: 043221
Cruise From:
Was £8584pp Now: £8240pp

7 Night Galapagos Inner Loop Itinerary

Baltra Island | Rabida Island | Puerto Egas | Elizabeth Bay | Tagus Cove | Bartolome Island | Sullivan Bay | Daphne Major | North Seymour Island | Las Bachas | Punta Pitt | Puerto Baquerizo Moreno | Puerto Ayora | Baltra Island

  • 02 Jul 2028
  • 7 Nights
Cruise From:
Was £8584pp Now: £8240pp
View cruise
Holiday ID: 071695
Cruise From:
Was £514pp Now: £493pp

7-Day Mexican Riviera

Los Angeles | Cabo San Lucas | Mazatlán | Puerto Vallarta | Los Angeles

  • 08 Apr 2028
  • 7 Nights

Interest free Monthly Payments from JUST £33pp

Cruise From:
Was £514pp Now: £493pp
View cruise
Holiday ID: 049435
Cruise From:
Was £1079pp Now: £1035pp

6-Day Pacific Coastal Cruise

San Diego | Santa Barbara | Astoria | Victoria | Vancouver

  • 17 Apr 2028
  • 6 Nights

Interest free Monthly Payments from JUST £72pp

Cruise From:
Was £1079pp Now: £1035pp
View cruise
Holiday ID: 067759

Prices are subject to change and availability. Prices may vary depending on the airport selected. Promotions are only applicable to select cabin grades, please call for details.

With such a vast number of itineraries to choose from, it can be beneficial to enlist the help of an expert to help you find the best deals. Our Cruise Concierge team can search through all the available cruise offers to help you book your South American cruise holiday at the very best price. Just give us a call.

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This website will provide you with information on the financial protection that applies in the case of each holiday and travel service offered before you make your booking. At the time of booking, our Cruise Concierge will also confirm the financial protection applicable to your specific holiday. Please ask us for further information should you require it. The flight inclusive holidays on this website are financially protected by the ATOL scheme. But ATOL protection does not apply to all holiday and travel services listed on this website. If you do not receive an ATOL Certificate then the booking will not be ATOL protected. If you do receive an ATOL Certificate but all parts of your trip are not listed on it, those parts will not be ATOL protected. The cruise-only holidays on this website are financially protected by ABTA. Please see our booking terms and conditions for further information or for more information about financial protection and the ATOL Certificate, click here. Cruise118 acts as a retail agent to you and also as a disclosed agent of the holiday provider (the Organiser of the holiday). The Foreign & Commonwealth Office have up-to-date advice on staying safe and healthy abroad. Visit the foreign travel advice site for the latest travel updates.
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